upcarta
  • Sign In
  • Sign Up
  • Explore
  • Search

Alternating sources of perisomatic inhibition during behavior - PubMed

  • Paper
  • Mar, 2021
  • #Neuroscience
Barna Dudok
@barnadudok
(Author)
pubmed.ncbi.nlm.nih.gov
Read on pubmed.ncbi.nlm.nih.gov
1 Recommender
1 Mention
Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and... Show More

Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior.

Show Less
Recommend
Post
Save
Complete
Collect
Mentions
See All
Yohan John @dryohanjohn · Apr 26, 2023
  • Post
  • From Twitter
Good day for reading about interneurons, it seems.
  • upcarta ©2025
  • Home
  • About
  • Terms
  • Privacy
  • Cookies
  • @upcarta