The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.
Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.
Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.
Please enjoy!
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This episode is also brought to you by Levels! I wrote about the health benefits of using continuous glucose monitors (CGMs) more than ten years ago in The 4-Hour Body. At the time, CGMs were primitive and hard to use. Levels has now made this technology, and the unique insights that come from it, easy and available to everyone. Levels is making glucose monitoring simple, helping you see how food affects your health through real-time feedback. I started tracking my glucose years ago to learn more about what I should and shouldn’t be eating (including quantities, time of day, etc.), based on objective data from my own, unique physiology. Keeping my blood sugar stable is critical to my daily and long-term health and performance goals. Furthermore, poor glucose control is associated with a number of chronic conditions like diabetes, Alzheimer’s disease, heart disease, and obesity. It’s important.
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[06:44] What is aging biology?
[08:43] How Matt pivoted from mathematics to biology.
[11:46] What is the Dog Aging Project?
[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.
[20:23] Rapamycin vs. sterile inflammation.
[23:07] Current thoughts about how the immune system changes as we age.
[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).
[42:20] Rapamycin and the Dog Aging Project.
[45:30] Rapamycin vs. neurodegeneration.
[48:21] What studies tell us about rapamycin’s potential to increase lifespan.
[51:30] Rapamycin alternatives considered for the Dog Aging Project.
[57:05] Urolithin A and spermidine.
[59:45] 17 alpha estradiol.
[1:01:47] Deprenyl.
[1:03:54] NAD precursors.
[1:05:52] What is Matt doing to increase his own lifespan/healthspan?
[1:09:00] Is time-restricted feeding beneficial for dogs?
[1:17:08] Currently, how well (or poorly) funded is longevity research?
[1:22:02] Where additional funding in this field would be best leveraged.
[1:35:19] Cutting through the hype and snake oil.
[1:42:26] Metformin.
[1:45:24] NAD infusion vs. natural NAD replenishment.
[1:48:16] Sirtuins.
[1:52:30] Resveratrol.
[2:08:58] Is there a fix to liability in defensive medicine?
[2:10:48] Finding better motivations for scientific pursuit.
[2:15:48] Longevity scientists worth checking out.
[2:17:39] Getting involved with the Dog Aging Project / parting thoughts.
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